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leflunomide side effecs and sulphasalazine Options
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ladygolfer
#1 Posted : Monday, February 21, 2011 2:24:58 PM Quote
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Joined: 12/7/2009
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Dear All

I am currently on 25mgs MTX by injection and 200 mgs of Hydroxocholoquine (daily). My RA is currently not under control and I was put on leflunomide (triple therapy), however I have had awful side effects after only taking this drug for 3 weeks (violent headache & hair loss). I have spoken to the rheummy nurse this morning and he is going to speak to the specialist about me taking sulphasalazine instead. I am wondering if I will experience the same side effects. This is the last chance saloon for me taking DMARDS, and I really want a third drug to work rather than go onto the ANTI TNF therapy drugs. I have looked through the drugs section before posting this to see if I could see if anyone has had side effects with sulphasalazine. I did not find anything so I am hoping that this is a good sign!!. So please can you let me know if you are taking this drug if you get any side effects or not.

Thanks

Val
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Rose-B
#2 Posted : Monday, February 21, 2011 2:58:49 PM Quote
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Location: Somerset


Hello Val,



I has on leflu for couple months last year and similar to you I had the migrane type head making me lie down and slight hair loss.
Sorry not what you want to hear. I have also been on mtx hydro and sulph which failed. I hope you get the right result.
Unfortunatley for me I am now due to start TNF / Humira very shortly


Good luck Rose
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flw93
#3 Posted : Monday, February 21, 2011 4:03:57 PM Quote
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Location: Stockton on Tees, Cleveland
Hi

I am on Enbrel and Leflunomide with no side effects if that is any help. I was originally on leflunomide and sulphalasine, but the sulphalasine brought me out in a rash from head to foot so I was taken off that.

Hope that helps.

Louise
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LynW
#4 Posted : Monday, February 21, 2011 7:33:19 PM Quote
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Location: Thornton Cleveleys
Hi Val

Unfortunately we all react differently to the drugs and what's right for one will be over the top for another.

I have done the rounds of DMARDS and failed and am on my second anti-tnf, Enbrel. I had Leflunomide added in December and it has made me worse than ever; along with obnoxious side effects. I had already failed on this once ... but nothing left to try! I stopped Leflunomide on Friday. I did previously experience the same side effects with sulfasalasine. I think a lot of people have problems with both these drugs.

I am not sure why people have a fear of anti-tnf, it is there to help people control a disease process that cannot otherwise be controlled. It is not to be feared! It is simply another treatment option.

I hope you find something suitable Val,

Lyn x
My son, Ian, completed the BUPA Great North Run on 15th September running for the National Rheumatoid Arthritis Society (NRAS). You can read his story at http://www.justgiving.com/ianlukewilson

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Glenys-H
#5 Posted : Monday, February 21, 2011 9:26:08 PM Quote
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Hi Val, I took Sulphasalazine for four and a half years when I was first diagnosed and had good results and the only side effect was I had very yellow wee. Good luck with yours I hope it goes as well for you.Glenys.
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Paula-C
#6 Posted : Tuesday, February 22, 2011 3:53:36 PM Quote
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Hello Val

I've been taking SLZ for nearly three years now (sorry still can't spell it right) and I have had no side effects at all. Not even the orange wee that seems to be the most common one. But like Lyn said everyone is different, I've had no side effects from MTX either and I am currently taking 20mg.

Paula x
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Kathryn-H
#7 Posted : Tuesday, February 22, 2011 4:05:20 PM Quote
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Location: Horsham, West Sussex
Hi Val

I tried Sulphasalazine last year for a few months alongside continuing MTX but had to stop because of psychological side effects. I suffer from depression which is generally well controlled by medication but the Sulphasalazine triggered a severe relapse. Needless to say, I stopped! I think it's only a very small percentage of people who experience this type of side effect.

Good luck!

Kathryn
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